Folligen for Health of Transplanted Hair

Folligen products are often used to enhance scalp and new hair health and hair growth after transplant procedures. Such hair often recovers slowly from shock of transplantation. Copper-peptide products can enhance the health of transplants and lead to an increased number of viable hair shafts.

Folligen for Health of Transplanted Hair
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Copper-peptides were first used in 1984 for skin transplantation . The bathing of skin transplants in 1% copper-peptide solutions produced greatly improved graft acceptance. The inclusion of 5% DMSO in the copper-peptide mixture improved transplant acceptance even further.

A new product based on patents by Dr. Loren Pickart, which is called GraftCyte, when used in the post-operative regimen has resulted in faster healing of transplants and earlier regrowth of the hair shafts. GraftCyte is a copper peptide based on the Iamin tissue regenerative concept. (For details, visit Copper Peptide Regeneration.) The GraftCyte dressing provides enhanced healing of the transplanted follicle. It results in less post-operative shedding along with a more immediate hair growth. Patients often see new hair growth in 6 weeks versus the normal 10 to 14 weeks. The normal skin crusting after transplantation has been reduced from 10 to 14 days to 5 days in most cases. GraftCyte costs about $275 per procedure and can be obtained from www.procyte.com/.

In a study of Graftcyte by Perez-Meza et al, (International Journal of Cosmetic Surgery (Vol. 6, 1998, pp 80-84), it was found that men and women receiving transplants and using GraftCyte for post-operative treatment achieved better results and a quicker healing time in comparison the conventional saline gauze dressing used after surgery. In a placebo-controlled, double blinded study of twelve patients were studied over a 13 week period, each patient received 16 treatments during 4 days post-surgery. On each patient, one side of the head was treated with conventional and the other with Graftcyte. Each patient received a conventional saline gauze dressing on one side of the head and GraftCyte on the other in a pre-assigned random scheme. Weekly results were documented by photographs and video microscopic scans. The study measured edema (excess fluid buildup and crusting), effluvium (shedding of transplanted hair), erythema (redness of the skin), the growth of transplanted hair that did not shed, and the regrowth of transplanted hair that returned after shedding plus overall cosmetic results.

In the Graftcyte treated areas, 42% of patients were found to exhibit less redness and crusting than on the placebo side vs 17% who were better with the saline; on the placebo side. Redness and crusting were slightly milder in the Graftcyte treated group (75% none to mild for GraftCyte and 58% for placebo). The GraftCyte treated side showed better hair regrowth at 4, 8, and 12 weeks compared to the placebo side. The patients felt that the GraftCyte treated hairs had greater body, shine, and texture than the placebo-treated side.

Effect of Graftcyte on Growth Transplanted Hair
(0=none, 1=mild, 2=moderate, 3=extensive)
	Placebo - Average Score	GraftCyte - Average Score
Week 4	1.3	1.6
Week 8	1.3	1.8
Week 12	1.3	1.9

Compare to Concentrated Graftcyte Solution®
5.7 ounces for $125.00.
But Folligen Solution has 9.0 times more copper peptide per ounce!
(Source - Evergreen Analytical Labs, Redmond, WA)

Other more advanced copper-peptide skin and hair growth accelerators are also available from such as Protect & Restore and Folligen which some physicians used after transplant. These accelerators have been proven effective in skin repair studies, and stimulate hair growth in mouse models, but as yet have not undergone controlled studies on hair transplantation.

For clinical data on Skin Biology's (www.skinbio.com/ skin healing accelerators see: (1) Zhai, Leow, and Maibach, "Sodium lauryl sulfate damaged skin in vivo in man: a water barrier repair model", Skin Research and Technology, Volume 4, pages 24-27, 1998. Skin Biology's product markedly accelerated the repair of skin damaged by the application of an irritating detergent. (2) Zhai, Poblete, and Maibach, "Stripped skin model to predict irritation potential of topical agents in vivo in man", International Journal of Dermatology, Volume 37, pages 386-389, 1998; Skin Biology product increased skin repair after skin removal by repeated tape-stripping. (3) Zhai, Leow, and Maibach, "Human barrier recovery after acute acetone perturbation: an irritant dermatitis model", Clinical and Experimental Dermatology, Volume 23, pages 11-13, 1998. Skin was damaged by a fat removing agent, acetone, then treated with a Skin Biology product which rapidly rebuilt the damaged skin, and (4) Zhai, Chang, Singh, and Maibach, "An in vivo nickel allergy contact dermatitis human model for topical therapeutics", Presented in February 1998, American Academy of Dermatology Meeting. Skin was damaged by the application of nickel salts to persons with nickel allergy. The Skin Biology product increased skin repair and reduced skin irritation.

Four months after my last transplants, my transplant area was still had redness and irritation. After 2 weeks of using Folligen Lotion, all of the redness and irritation is gone.

I used Folligen after my third hair transplant. There is good growth and I am still getting new hairs after 4 months. I have no scarring. I used Folligen cream and the spray which I diluted 50% with water.

The first time I had transplants, I used Graftcyte afterward and had good results. But, for my second transplants, I used Folligen Solution and had much better hair outgrowth. I dilute the Folligen Solution with three parts of water and this spray it on the transplanted area.

I have been using Folligen on my hair transplant patients for more than a year. It gives great results.

My hair grafts really started to grow rapidly with Folligen. Before, the just sat there for months.

I have been using Folligen on my hair transplants with good results. I have had previous hair transplants and the transplants take about five months to start growing out. After my last transplants, I applied a light coating of Folligen to my scalp then washed it off in the morning. This time my hair spouted out after two months. I also think that greater numbers of hair came from each transplant than previously.

I'm ordering 10 more Folligen® Lotions. I had hair transplants and a substantial amount of irritation had developed around the transplants. The Folligen® has been very helpful in resolving this problem. The scalp irritation has disappeared, itching has stopped and the transplant areas look much better.